In everyday clinical practice, there are many texts such as doctor’s letters and findings that contain valuable information about the patient’s medical history, progression and treatment. With the help of these texts, programs for the automatic processing of natural language (natural language processing, NLP for short) could support doctors and researchers in their work. However, the full potential of clinical documents cannot be exploited due to a lack of standardization. The German Medical Text Corpus (GeMTeX) method platform aims to close this gap and aims to make medical texts from patient care available for research projects available. The aim is to create the largest medical text corpus in the German language. You might want to refer to the GeMTeX consoritum website for further details.
Fox, S., Preiß, M., Borchert, F., Rasheed, A., Schapranow, M.-P.: HPIDHC at NTCIR-17 MedNLP-SC: Data Augmentation and Ensemble Learning for Multilingual Adverse Drug Event Detection. NTCIR 17 Conference: Proceedings of the 17th NTCIR Conference on Evaluation of Information Access Technologies. bll. 185–192. , Tokyo, Japan (2023).
Borchert, F., Llorca, I., Schapranow, M.-P.: HPI-DHC @ BC8 SympTEMIST Track: Detection and Normalization of Symptom Mentions with SpanMarker and xMEN. In: Islamaj, R., Arighi, C., Campbell, I., Gonzalez-Hernandez, G., Hirschman, L., Krallinger, M., Lima-López, S., Weissenbacher, D., en Lu, Z. (reds.) Proceedings of the BioCreative VIII Challenge and Workshop: Curation and Evaluation in the era of Generative Models. , New Orleans, LA (2023).
Borchert, F., Llorca, I., Roller, R., Arnrich, B., Schapranow, M.-P.: xMEN: A Modular Toolkit for Cross-Lingual Medical Entity Normalization. arXiv preprint arXiv:2310.11275. (2023).
Borchert, F., Llorca, I., Schapranow, M.-P.: Cross-Lingual Candidate Retrieval and Re-ranking for Biomedical Entity Linking. In: Arampatzis, A., Kanoulas, E., Tsikrika, T., Vrochidis, S., Giachanou, A., Li, D., Aliannejadi, M., Vlachos, M., Faggioli, G., en Ferro, N. (reds.) Experimental IR Meets Multilinguality, Multimodality, and Interaction. bll. 135–147. Springer Nature Switzerland, Cham (2023).
Llorca, I., Borchert, F., Schapranow, M.-P.: A Meta-dataset of German Medical Corpora: Harmonization of Annotations and Cross-corpus NER Evaluation. Proceedings of the 5th Clinical Natural Language Processing Workshop. bll. 171–181. Association for Computational Linguistics, Toronto, Canada (2023).
Kämmer, N., and Borchert, F., and Winkler, S., and de Melo, G., and Schapranow, M.-P.: Resolving Elliptical Compounds in German Medical Text. The 22nd Workshop on Biomedical Natural Language Processing and BioNLP Shared Tasks. bll. 292–305. Association for Computational Linguistics, Toronto, Canada (2023).
Being fit and healthy even at high age is a high value for many people. A key factor in this is a healthy diet. People, who eat well and healthily throughout their lives, are less likely to be ill in old age. But how exactly is healthy nutrition defined? How healthy do older people in Germany eat? Would they even accept new nutrition recommendations? The competence cluster Nutritional Intervention for Healthy Aging (NutriAct) is investigating these questions in the Berlin-Potsdam area. The aim is to create the scientific basis for age-appropriate nutritional interventions and recommendations. In addition, new foods are to be developed that enable healthy nutrition. The cluster focuses in particular on the middle-aged population (50-70 years) in order to promote healthy aging beyond the age of 70. To this end, the neurobiological, psychological, social and familial basis of food choices and, in particular, their influencing factors within family structures, will be analyzed. In addition, research will be conducted to determine whether sociocultural factors influence taste preferences and dietary practices. A central question here is the significance of gender-specific effects in connection with taste orientations within a partnership. In addition, the extent to which moments of upheaval, such as the transition to retirement, separation, or an illness, influence eating practices will be examined. On the basis of the nutrition pattern analyses, realistically implementable nutrition recommendations will be developed. The central element of the cluster is an intervention study in which the effectiveness, adherence and acceptance of the NutriAct dietary pattern rich in plant proteins, fiber and unsaturated fatty acids will be systematically tested. Based on this, new healthy and palatable foods will be developed that will be accepted by consumers. Accompanying this will be the identification of new biomarkers that predict the effects of a particular diet on health status, especially in old age.
The German-Canadian consortium NephroCAGE is cooperating to demonstrate the added value of artificial intelligence (AI) using the concrete clinical example of kidney transplantation. Inadequate kidney function requires regular dialysis: there are currently around 100,000 dialysis patients in Germany, and around half that number in Canada. Dialysis costs approximately 30-40k EUR per patient per year. In comparison, a kidney transplant costs around 15-20 thousand euros. In 2019, more than 2,100 kidney transplants were performed in Germany (German Organ Transplant Foundation) and more than 1,700 in Canada (Canadian Institute for Health in Canada). However, suitable donor organs are rare: in Germany, for example, there are more than 7,000 patients on a waiting list, and in Canada more than 3,000. Even after a transplant, there is a risk of complications that can lead to severe limitations in kidney function or, in the worst case, even total loss of the organ.
The consortium partners are creating a learning AI system to match organ donors and recipients even more precisely in advance (matching) and thus prevent risks in kidney transplants. To this end, clinical centers of excellence in both nations are contributing transplant data from the last ten years. They will be analyzed using AI learning techniques and combined together with a novel matching algorithm to create clinical prognostic models for kidney transplant patients. By using a federated learning approach, where the algorithms are executed at the location of the data, data protection is maintained and sensitive health data from both nations can serve as a common basis for clinical prognostic models for the first time. As a result, a clinical demonstrator will be created to serve the exploitation of the medical and technical innovations in the context of care, as well as a basis for exploitation and follow-on projects.
Project Partners
Canada
The University of British Columbia, Faculty of Medicine, Department of Pathology and Laboratory Medicine, Vancouver, British Columbia
Genome BC, Vancouver, British Columbia
Genome Canada, Ontario, Ottawa
McGill University Health Centre, Montréal, Québec
Centre hospitalier de l’Université de Montréal, Québec
Schapranow, M.-P.: NephroCAGE: Wie Künstliche Intelligenz bei Nierenversagen unterstützen kann. Gesundhyte: Forschung neu vernetzen. 15, 100—102 (2023).
Schapranow, M.-P., Bayat, M., Rasheed, A., Naik, M., Graf, V., Schmidt, D., Budde, K., Cardinal, H., Sapir-Pichhadze, R., Fenninger, F., Sherwood, K., Keown, P., Günther, O., Pandl, K., Leiser, F., Thiebes, S., Sunyaev, A., Niemann, M., Schimanski, A., Klein, T.: NephroCAGE—German-Canadian Consortium on AI for Improved Kidney Transplantation Outcome: Protocol for an Algorithm Development and Validation Study. JMIR Res Protoc 2023. 12, (2023).
Borchert, F., Llorca, I., Schapranow, M.-P.: Cross-Lingual Candidate Retrieval and Re-ranking for Biomedical Entity Linking. In: Arampatzis, A., Kanoulas, E., Tsikrika, T., Vrochidis, S., Giachanou, A., Li, D., Aliannejadi, M., Vlachos, M., Faggioli, G., en Ferro, N. (reds.) Experimental IR Meets Multilinguality, Multimodality, and Interaction. bll. 135–147. Springer Nature Switzerland, Cham (2023).
Llorca, I., Borchert, F., Schapranow, M.-P.: A Meta-dataset of German Medical Corpora: Harmonization of Annotations and Cross-corpus NER Evaluation. Proceedings of the 5th Clinical Natural Language Processing Workshop. bll. 171–181. Association for Computational Linguistics, Toronto, Canada (2023).
Kämmer, N., and Borchert, F., and Winkler, S., and de Melo, G., and Schapranow, M.-P.: Resolving Elliptical Compounds in German Medical Text. The 22nd Workshop on Biomedical Natural Language Processing and BioNLP Shared Tasks. bll. 292–305. Association for Computational Linguistics, Toronto, Canada (2023).
The project is generously sponsored by the German Federal Ministry for Economic Affairs and Climate Action (2021-2022) as project of strategic interest.
BigMedilytics is an international collaboration between partners from academia and industry across Europe. It aims to transform Europe’s Healthcare sector by using state-of-the-art Big Data technologies to achieve breakthrough productivity in the sector by reducing cost, improving patient outcomes and delivering better access to healthcare facilities simultaneously, covering the entire Healthcare Continuum – from Prevention to Diagnosis, Treatment and Home Care throughout Europe.
In particular, we are focusing on applying latest big data and machine learning technologies to the BigMedilytics project use case nephrology to measure and analyze clinical performance indicators, integrate predicitive models, and measure their impact on clinical routine.
Project Partners
Philips Electronics Nederland B.V., Netherlands
Fundacion Pala La Investiogation Del Hospital Clinico De La Comunitat Valencia, Fundacion Incliva, Spain
Instituto Technologico De Informatica, Spain
ERASMUS Universitait Medisch Centrum Rotterdam, Netherlands
ACHMEA BV, Netherlands
GIE AXA, France
OPTIMEDIS AG, Germany
ATOS Spain SA, Spain
Nederlandse Organisatie voor Toegepast-natuurwetenschappelijk onderzoek TNO, Netherlands
Technische Universiteit Eindhoven, Netherlands
HUAWEI Technologies Düsseldorf GMBH, Germany
Royal College of Surgeons in Ireland, Ireland
Stockholms Lans Landsting, Sweden
National Center for Scientific Research “Demokritos”, Greece
In the following, we assembled related content that might be of your particular interest.
Events
Publications
Research Publications
Freitas da Cruz, H., Bergner, B., Konak, O., Schneider, F., Bode, P., Lempert, C., Schapranow, M.-P.: MORPHER – A Platform to Support Modeling of Outcome and Risk Prediction in Health Research. Proceedings of the 19th IEEE International Conference on Bioinformatics and Biomedicine. , Athens, Greece (2019).
Freitas da Cruz, H., Horschig, S., Nusshag, C., Schapranow, M.-P.: Knowledge Distillation from Machine Learning Models for Prediction of Hemodialysis Outcomes. International Journal On Advances in Life Sciences. 11, 33–43 (2019).
Freitas da Cruz, H., Pfahringer, B., Schneider, F., Meyer, A., Schapranow, M.-P.: External Validation of a Black-Box Clinical Predictive Model in Nephrology: Can Interpretability Methods Help Illuminate Performance Differences?. Proceedings of 17th Conference on Artificial Intelligence in Medicine. bll. 191–201 (2019).
Sponsors
2018-2021 European Commission in context of the H2020 research program.
Contact
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The HiGHmed consortium aims to develop and use innovative information infrastructures to increase the efficiency of clinical research and to swiftly translate research results into validated improvements of patient care. These aims are tightly connected with challenges to integrate and further develop solutions of innovative, internationally interoperable data integration and methods, with the aim to demonstrate their added value for health research and patient care. The concepts must be designed in a way that will help to develop sustainable structures and with the perspective for an easy roll-out to other hospitals. You might want to refer to the HiGHmed consoritum website for further details.
Project Partners
Heidelberg University Hospital (UKL-HD)
University Medical Center Göttingen (UMG)
Hannover Medical School (MHH)
University Hospital Schleswig-Holstein / Kiel University (UKSH)
Llorca, I., Borchert, F., Schapranow, M.-P.: A Meta-dataset of German Medical Corpora: Harmonization of Annotations and Cross-corpus NER Evaluation. Proceedings of the 5th Clinical Natural Language Processing Workshop. bll. 171–181. Association for Computational Linguistics, Toronto, Canada (2023).
Kämmer, N., and Borchert, F., and Winkler, S., and de Melo, G., and Schapranow, M.-P.: Resolving Elliptical Compounds in German Medical Text. The 22nd Workshop on Biomedical Natural Language Processing and BioNLP Shared Tasks. bll. 292–305. Association for Computational Linguistics, Toronto, Canada (2023).
Steinwand, S., Borchert, F., Winkler, S., Schapranow, M.-P.: GGTWEAK: Gene Tagging with Weak Supervision for German Clinical Text. In: Juarez, J.M., Marcos, M., Stiglic, G., en Tucker, A. (reds.) Artificial Intelligence in Medicine. bll. 183–192. Springer Nature Switzerland, Cham (2023).
Schapranow, M.-P., Borchert, F., Bougatf, N., Hund, H., Eils, R.: Software-Tool Support for Collaborative, Virtual, Multi-Site Molecular Tumor Boards. SN Computer Science. 4, 358 (2023).
Ladas, N., Borchert, F., Franz, S., Rehberg, A., Strauch, N., Sommer, K.K., Marschollek, M., Gietzelt, M.: Programming techniques for improving rule readability for rule-based information extraction natural language processing pipelines of unstructured and semi-structured medical texts. Health Informatics Journal. 29, 14604582231164696 (2023).
Richter-Pechanski, P., Wiesenbach, P., Schwab, D.M., Kiriakou, C., He, M., Allers, M.M., Tiefenbacher, A.S., Kunz, N., Martynova, A., Spiller, N., Mierisch, J., Borchert, F., Schwind, C., Frey, N., Dieterich, C., Geis, N.A.: A Distributable German Clinical Corpus Containing Cardiovascular Clinical Routine Doctor’s Letters. Scientific Data. 10, 207 (2023).
Borchert, F., Schapranow, M.-P.: HPI-DHC @ BioASQ DisTEMIST: Spanish Biomedical Entity Linking with Pre-trained Transformers and Cross-lingual Candidate Retrieval. Proceedings of the Working Notes of CLEF 2022 - Conference and Labs of the Evaluation Forum. bll. 244–258. , Bologna, Italy (2022).
Borchert, F., Lohr, C., Modersohn, L., Witt, J., Langer, T., Follmann, M., Gietzelt, M., Arnrich, B., Hahn, U., Schapranow, M.-P.: GGPONC 2.0 - The German Clinical Guideline Corpus for Oncology: Curation Workflow, Annotation Policy, Baseline NER Taggers. Proceedings of the Language Resources and Evaluation Conference. bll. 3650–3660. European Language Resources Association, Marseille, France (2022).
Henkenjohann, R., Bergner, B., Borchert, F., Bougatf, N., Hund, H., Eils, R., Schapranow, M.-P.: An Engineering Approach towards Multi-Site Virtual Molecular Tumor Board Software Support. In: Pissaloux, E., Papadopoulos, G., Achilleos, A., en Velázquez, R. (reds.) ICT for Health, Accessibility and Wellbeing. IHAW 2021. bll. 156–170. Springer, Cham (2022).
Ganzinger, M., Schapranow, M.-P.: FAIRe Datennutzung: Erfahrungen aus Verbundprojekten. gesundhyte.de: Das Magazin für Digitale Gesundheit in Deutschland. 14, 57–61 (2021).
Rasheed, A., Borchert, F., Kohlmeyer, L., Henkenjohann, R., Schapranow, M.-P.: A Comparison of Concept Embeddings for German Clinical Corpora. 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). bll. 2314–2321 (2021).
Borchert, F., Meister, L., Langer, T., Follmann, M., Arnrich, B., Schapranow, M.-P.: Controversial Trials First: Identifying Disagreement Between Clinical Guidelines and New Evidence. AMIA Annual Symposium Proceedings. bll. 237–246. American Medical Informatics Association (2021).
Borchert, F., Mock, A., Tomczak, A., Hügel, J., Alkarkoukly, S., Knurr, A., Volckmar, A.-L., Stenzinger, A., Schirmacher, P., Debus, J., Jäger, D., Longerich, T., Fröhling, S., Eils, R., Bougatf, N., Sax, U., Schapranow, M.-P.: Knowledge bases and software support for variant interpretation in precision oncology. Briefings in Bioinformatics. 22, (2021).
Borchert, F., Lohr, C., Modersohn, L., Hahn, U., Langer, T., Wenzel, G., Follmann, M., Schapranow, M.-P.: "Herr Doktor, verstehen Sie mich?“: Wie lernende Systeme helfen medizinische Fachsprache zu verstehen und welche Rolle klinische Leitlinien dabei spielen. gesundhyte.de: Das Magazin für Digitale Gesundheit in Deutschland. 13, 19–22 (2020).
Borchert, F., Lohr, C., Modersohn, L., Langer, T., Follmann, M., Sachs, J.P., Hahn, U., Schapranow, M.-P.: GGPONC: A Corpus of German Medical Text with Rich Metadata Based on Clinical Practice Guidelines. Proceedings of the 11th International Workshop on Health Text Mining and Information Analysis. bll. 38–48. Association for Computational Linguistics, Online (2020).
The cooperation project Systems Medicine of Heart Failure (SMART) focuses on researching risk factors of heart failures. The onset and course of heart failure (HF) is triggered by a complex regulatory network that includes stressors (pressure overload by individual anatomic hemodynamic settings), intrinsic (genes), environmental (regulating epigenetics), and modifying factors (such as hormones and the immune system). SMART aims to establish individualized strategies for the prevention and management of HF by early detection of the physiological, genomic, proteomic and hemodynamic mechanisms that lead from one common cause of ventricular dysfunction (pressure overload) to maladaptive remodeling and irreversible HF. To cope with the complexity of HF, SMART will interrelate models describing the interplay between genome, proteome and cell function, regulating hormones, tissue composition and hemodynamic whole organ function up to a whole body description of a patient and patient cohorts. The ultimate goal is to demonstrate proof-of-concept tools for predicting disease evolution and efficacy of treatment in a given patient. To achieve this task SMART will apply – A modelling framework that couples multi-scale mechanistic models with in-depth genome/proteome, cell physiology and whole organ (biomechanical and fluid dynamic) models – Subsequently, investigate methods validity and relevance for “quantitative prediction” of treatment outcome in a clinical proof-of-concept trial (demonstrator) of patients with aortic valve diseases.
Nordmeyer, S., Kraus, M., Ziehm, M., Kirchner, M., Schafstedde, M., Kelm, M., Niquet, S., Stephen, M., Baczko, I., Knosalla, C., Schapranow, M.-P., Dittmar, G., Gotthardt, M., Falcke, M., Regitz-Zagrosek, V., Kuehne, T., Mertins, P.: Disease- and sex-specific differences in patients with heart valve disease: A proteome study. Life Sci Alliance. 6, e202201411 (2023).
Kraus, M., Mathew Stephen, M., Schapranow, M.-P.: Eatomics: Shiny exploration of quantitative proteomics data. Journal of Proteome Research. (2020).
Slosarek, T., Kraus, M., Schapranow, M.-P., Bottinger, E.: Qualitative Comparison of Selected Indel Detection Methods for RNA-Seq Data. International Work-Conference on Bioinformatics and Biomedical Engineering. bll. 166–177. Springer (2019).
Kraus, M., Hesse, G., Slosarek, T., Danner, M., Kesar, A., Bhushan, A., Schapranow, M.-P.: DEAME-Differential Expression Analysis Made Easy. Heterogeneous Data Management, Polystores, and Analytics for Healthcare. bll. 162–174. Springer (2018).
Kraus, M., Schapranow, M.-P.: An In-Memory Database Platform for Systems Medicine. Proceedings of the International Conference on Bioinformatics and Computational Biology. bll. 93–100. The International Society for Computers and Their Applications (ISCA) (2017).
Kraus, M., Niedermeier, J., Jankrift, M., Tietboehl, S., Stachewicz, T., Folkerts, H., Uflacker, M., Neves, M.: Olelo: a web application for intuitive exploration of biomedical literature. Nucleic acids research. (2017).
Schapranow, M.-P., Kraus, M., Danner, M., Plattner, H.: IMDBfs: Bridging the Gap between In-Memory Database Technology and File-Based Tools for Life Sciences. Proceedings of the IEEE International Conference on Bioinformatics and Biomedicine. bll. 1133–1139. IEEE (2016).
Please feel free to get directly in touch with the experts. Use the following contact form, if you have any open questions you might to share with us.
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