Being fit and healthy even at high age is a high value for many people. A key factor in this is a healthy diet. People, who eat well and healthily throughout their lives, are less likely to be ill in old age. But how exactly is healthy nutrition defined? How healthy do older people in Germany eat? Would they even accept new nutrition recommendations? The competence cluster Nutritional Intervention for Healthy Aging (NutriAct) is investigating these questions in the Berlin-Potsdam area. The aim is to create the scientific basis for age-appropriate nutritional interventions and recommendations. In addition, new foods are to be developed that enable healthy nutrition. The cluster focuses in particular on the middle-aged population (50-70 years) in order to promote healthy aging beyond the age of 70. To this end, the neurobiological, psychological, social and familial basis of food choices and, in particular, their influencing factors within family structures, will be analyzed. In addition, research will be conducted to determine whether sociocultural factors influence taste preferences and dietary practices. A central question here is the significance of gender-specific effects in connection with taste orientations within a partnership. In addition, the extent to which moments of upheaval, such as the transition to retirement, separation, or an illness, influence eating practices will be examined. On the basis of the nutrition pattern analyses, realistically implementable nutrition recommendations will be developed. The central element of the cluster is an intervention study in which the effectiveness, adherence and acceptance of the NutriAct dietary pattern rich in plant proteins, fiber and unsaturated fatty acids will be systematically tested. Based on this, new healthy and palatable foods will be developed that will be accepted by consumers. Accompanying this will be the identification of new biomarkers that predict the effects of a particular diet on health status, especially in old age.
The German-Canadian consortium NephroCAGE is cooperating to demonstrate the added value of artificial intelligence (AI) using the concrete clinical example of kidney transplantation. Inadequate kidney function requires regular dialysis: there are currently around 100,000 dialysis patients in Germany, and around half that number in Canada. Dialysis costs approximately 30-40k EUR per patient per year. In comparison, a kidney transplant costs around 15-20 thousand euros. In 2019, more than 2,100 kidney transplants were performed in Germany (German Organ Transplant Foundation) and more than 1,700 in Canada (Canadian Institute for Health in Canada). However, suitable donor organs are rare: in Germany, for example, there are more than 7,000 patients on a waiting list, and in Canada more than 3,000. Even after a transplant, there is a risk of complications that can lead to severe limitations in kidney function or, in the worst case, even total loss of the organ.
The consortium partners are creating a learning AI system to match organ donors and recipients even more precisely in advance (matching) and thus prevent risks in kidney transplants. To this end, clinical centers of excellence in both nations are contributing transplant data from the last ten years. They will be analyzed using AI learning techniques and combined together with a novel matching algorithm to create clinical prognostic models for kidney transplant patients. By using a federated learning approach, where the algorithms are executed at the location of the data, data protection is maintained and sensitive health data from both nations can serve as a common basis for clinical prognostic models for the first time. As a result, a clinical demonstrator will be created to serve the exploitation of the medical and technical innovations in the context of care, as well as a basis for exploitation and follow-on projects.
The University of British Columbia, Faculty of Medicine, Department of Pathology and Laboratory Medicine, Vancouver, British Columbia
BigMedilytics is an international collaboration between partners from academia and industry across Europe. It aims to transform Europe’s Healthcare sector by using state-of-the-art Big Data technologies to achieve breakthrough productivity in the sector by reducing cost, improving patient outcomes and delivering better access to healthcare facilities simultaneously, covering the entire Healthcare Continuum – from Prevention to Diagnosis, Treatment and Home Care throughout Europe.
In particular, we are focusing on applying latest big data and machine learning technologies to the BigMedilytics project use case nephrology to measure and analyze clinical performance indicators, integrate predicitive models, and measure their impact on clinical routine.
Philips Electronics Nederland B.V., Netherlands
Fundacion Pala La Investiogation Del Hospital Clinico De La Comunitat Valencia, Fundacion Incliva, Spain
Instituto Technologico De Informatica, Spain
ERASMUS Universitait Medisch Centrum Rotterdam, Netherlands
ACHMEA BV, Netherlands
GIE AXA, France
OPTIMEDIS AG, Germany
ATOS Spain SA, Spain
Nederlandse Organisatie voor Toegepast-natuurwetenschappelijk onderzoek TNO, Netherlands
Technische Universiteit Eindhoven, Netherlands
HUAWEI Technologies Düsseldorf GMBH, Germany
Royal College of Surgeons in Ireland, Ireland
Stockholms Lans Landsting, Sweden
National Center for Scientific Research “Demokritos”, Greece
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1.Freitas da Cruz, H., Bergner, B., Konak, O., Schneider, F., Bode, P., Lempert, C., Schapranow, M.-P.: MORPHER – A Platform to Support Modeling of Outcome and Risk Prediction in Health Research. Proceedings of the 19th IEEE International Conference on Bioinformatics and Biomedicine. , Athens, Greece (2019).
2.Freitas da Cruz, H., Horschig, S., Nusshag, C., Schapranow, M.-P.: Knowledge Distillation from Machine Learning Models for Prediction of Hemodialysis Outcomes. International Journal On Advances in Life Sciences. 11, 33–43 (2019).
3.Freitas da Cruz, H., Pfahringer, B., Schneider, F., Meyer, A., Schapranow, M.-P.: External Validation of a Black-Box Clinical Predictive Model in Nephrology: Can Interpretability Methods Help Illuminate Performance Differences?. Proceedings of 17th Conference on Artificial Intelligence in Medicine. bll. 191–201 (2019).
2018-2021 European Commission in context of the H2020 research program.
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The HiGHmed consortium aims to develop and use innovative information infrastructures to increase the efficiency of clinical research and to swiftly translate research results into validated improvements of patient care. These aims are tightly connected with challenges to integrate and further develop solutions of innovative, internationally interoperable data integration and methods, with the aim to demonstrate their added value for health research and patient care. The concepts must be designed in a way that will help to develop sustainable structures and with the perspective for an easy roll-out to other hospitals. You might want to refer to the HiGHmed consoritum website for further details.
Heidelberg University Hospital (UKL-HD)
University Medical Center Göttingen (UMG)
Hannover Medical School (MHH)
University Hospital Schleswig-Holstein / Kiel University (UKSH)
1.Rasheed, A., Borchert, F., Kohlmeyer, L., Henkenjohann, R., Schapranow, M.-P.: A Comparison of Concept Embeddings for German Clinical Corpora. 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). bll. 2314–2321 (2021).
2.Henkenjohann, R., Bergner, B., Borchert, F., Bougatf, N., Hund, H., Eils, R., Schapranow, M.-P.: An Engineering Approach towards Multi-Site Virtual Molecular Tumor Board Software Support. Proceedings of the 1st Conference on ICT for Health, Accessibility and Wellbeing. Springer International Publishing (2021).
3.Borchert, F., Meister, L., Langer, T., Follmann, M., Arnrich, B., Schapranow, M.-P.: Controversial Trials First: Identifying Disagreement Between Clinical Guidelines and New Evidence. AMIA Annual Symposium Proceedings. bll. 236–245 (2021).
4.Borchert, F., Mock, A., Tomczak, A., Hügel, J., Alkarkoukly, S., Knurr, A., Volckmar, A.-L., Stenzinger, A., Schirmacher, P., Debus, J., Jäger, D., Longerich, T., Fröhling, S., Eils, R., Bougatf, N., Sax, U., Schapranow, M.-P.: Knowledge bases and software support for variant interpretation in precision oncology. Briefings in Bioinformatics. 22, (2021).
5.Borchert, F., Lohr, C., Modersohn, L., Hahn, U., Langer, T., Wenzel, G., Follmann, M., Schapranow, M.-P.: "Herr Doktor, verstehen Sie mich?“: Wie lernende Systeme helfen medizinische Fachsprache zu verstehen und welche Rolle klinische Leitlinien dabei spielen. gesundhyte.de: Das Magazin für Digitale Gesundheit in Deutschland. 13, 19–22 (2020).
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The cooperation project Systems Medicine of Heart Failure (SMART) focuses on researching risk factors of heart failures. The onset and course of heart failure (HF) is triggered by a complex regulatory network that includes stressors (pressure overload by individual anatomic hemodynamic settings), intrinsic (genes), environmental (regulating epigenetics), and modifying factors (such as hormones and the immune system). SMART aims to establish individualized strategies for the prevention and management of HF by early detection of the physiological, genomic, proteomic and hemodynamic mechanisms that lead from one common cause of ventricular dysfunction (pressure overload) to maladaptive remodeling and irreversible HF. To cope with the complexity of HF, SMART will interrelate models describing the interplay between genome, proteome and cell function, regulating hormones, tissue composition and hemodynamic whole organ function up to a whole body description of a patient and patient cohorts. The ultimate goal is to demonstrate proof-of-concept tools for predicting disease evolution and efficacy of treatment in a given patient. To achieve this task SMART will apply – A modelling framework that couples multi-scale mechanistic models with in-depth genome/proteome, cell physiology and whole organ (biomechanical and fluid dynamic) models – Subsequently, investigate methods validity and relevance for “quantitative prediction” of treatment outcome in a clinical proof-of-concept trial (demonstrator) of patients with aortic valve diseases.
1.Kraus, M., Mathew Stephen, M., Schapranow, M.-P.: Eatomics: Shiny exploration of quantitative proteomics data. Journal of Proteome Research. (2020).
2.Slosarek, T., Kraus, M., Schapranow, M.-P., Bottinger, E.: Qualitative Comparison of Selected Indel Detection Methods for RNA-Seq Data. International Work-Conference on Bioinformatics and Biomedical Engineering. bll. 166–177. Springer (2019).
3.Kraus, M., Hesse, G., Slosarek, T., Danner, M., Kesar, A., Bhushan, A., Schapranow, M.-P.: DEAME-Differential Expression Analysis Made Easy. Heterogeneous Data Management, Polystores, and Analytics for Healthcare. bll. 162–174. Springer (2018).
4.Kraus, M., Schapranow, M.-P.: An In-Memory Database Platform for Systems Medicine. Proceedings of the International Conference on Bioinformatics and Computational Biology. bll. 93–100. The International Society for Computers and Their Applications (ISCA) (2017).
5.Kraus, M., Niedermeier, J., Jankrift, M., Tietboehl, S., Stachewicz, T., Folkerts, H., Uflacker, M., Neves, M.: Olelo: a web application for intuitive exploration of biomedical literature. Nucleic acids research. (2017).
6.Schapranow, M.-P., Kraus, M., Danner, M., Plattner, H.: IMDBfs: Bridging the Gap between In-Memory Database Technology and File-Based Tools for Life Sciences. Proceedings of the IEEE International Conference on Bioinformatics and Biomedicine. bll. 1133–1139. IEEE (2016).