The cooperation project Systems Medicine of Heart Failure (SMART) focuses on researching risk factors of heart failures. The onset and course of heart failure (HF) is triggered by a complex regulatory network that includes stressors (pressure overload by individual anatomic hemodynamic settings), intrinsic (genes), environmental (regulating epigenetics), and modifying factors (such as hormones and the immune system). SMART aims to establish individualized strategies for the prevention and management of HF by early detection of the physiological, genomic, proteomic and hemodynamic mechanisms that lead from one common cause of ventricular dysfunction (pressure overload) to maladaptive remodeling and irreversible HF. To cope with the complexity of HF, SMART will interrelate models describing the interplay between genome, proteome and cell function, regulating hormones, tissue composition and hemodynamic whole organ function up to a whole body description of a patient and patient cohorts. The ultimate goal is to demonstrate proof-of-concept tools for predicting disease evolution and efficacy of treatment in a given patient. To achieve this task SMART will apply
– A modelling framework that couples multi-scale mechanistic models with in-depth genome/proteome, cell physiology and whole organ (biomechanical and fluid dynamic) models
– Subsequently, investigate methods validity and relevance for “quantitative prediction” of treatment outcome in a clinical proof-of-concept trial (demonstrator) of patients with aortic valve diseases.
- German Heart Institute Berlin
- Max Delbrück Center for Molecular Medicine
- Bayer Technology GmbH
- Charité University Medicine Berlin
- Hasso Plattner Institute and AnalyzeGenomes.com
In the following, we assembled related content that might be of your particular interest.
- 2017 International Conference on Bioinformatics and Computational Biology (BICOB) on March 20, 2017
- Join us for the 2017 Telematics Conference in Potsdam, Germany on February 22, 2017
- Join us for the 2016 e:Med Meeting on Systems Medicine in Kiel on October 4, 2016
- Join us for the Usedom Heart Insufficiency Symposium on June 18, 2016
- Join us for the e:Med Workshop on “Data Management in Systems Medicine” on June 9, 2016
- Join us for the 2016 CeBIT in Hanover, Germany on March 14, 2016
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- Systems Medicine of Heart Failure (SMART) cooperation project launched
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